Vortioxetine for Major Depressive Disorder User Reviews (Page 5)

• Augus...
• Taken for less than 1 month
• November 13, 2018

Trintellix (vortioxetine) "I have been taking 10 mg for a week and no side effects whatsoever. For the first time in years I am sleeping through the night (I take it at bedtime) and wake up rested. It's not meant to be sleep aide, but it certainly is a nice side effect. With my anxiety and depression, I'm usually up at 2:00 am and wandering around my house for a few hours so this is a welcome change. I'm only seeing marginal increase in my depression but I suspect, being that I am tolerating it very well, I will get bumped up to a higher dose. The only potential side effect (I say potential because it's only been a week) is that my appetite is not as good as normal (forgetting to eat meals and when do, feel full much quicker). Will update as I move up in dosage."

• Dee
• Taken for less than 1 month
• July 3, 2019

Trintellix (vortioxetine) "I have switched to Trintellix about 2 weeks ago from Celexa, which I had been on for 10+ years. My sex drive is back, more vivid, colorful dreams and just feeling so much more positive thoughts and overall good feeling!"

• Tracy
• Taken for 6 months to 1 year
• September 6, 2017

Trintellix (vortioxetine) "I've been on Trintellix 20 mg x 10 months, 53-year-old female with long-standing, chronic MDD & anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times & in my 30's, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses, or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; hasn't been a "miracle" drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, & 10 mg Adderall daily."

• SDano
• Taken for 1 to 6 months
• February 20, 2020

Trintellix (vortioxetine) "Hello everyone! I started trintellix in the middle of January at 5 mg. The side effects were horrible. I remember that on the second day I vomited on the street while I was having a walk. I also had other side effects. After the first week, things started to change slowly for the better. After the second week, I took 10 mg. During the six week when I broke up with my boyfriend and everything felt apart. The medication stopped working and my depression got worse. I was on the way to kill myself. Everything was so serious and I decided to go back to my home town where is my family and therapist. For 3 weeks I have been on Effexor XR and I cannot say I see a positive change but I feel hopeful that things will change for the better. I rate Trintelix with 2 because it had awful side effects and it didn't help me at the end. I wish luck to everyone reading this. You are not alone!"

• MrsG
• Taken for 6 months to 1 year
• December 28, 2019

Trintellix (vortioxetine) "So Trintellix was weird for me. 20mgs worked well for my depression but triggered some awful OCD episodes. If you have OCD or anxiety, you might want to stay away from this one. The nausea was not fun. Even when taken with a dose of Zofran (anti nausea pill), my stomach would gurgle and churn all morning. I also had insomnia and when I finally did fall asleep, I’d have weird and sometimes disturbing dreams. Positive things about it. I didn’t gain any weight and had no sexual side effects. Antidepressants are all different and this particular one didn’t really work for me. But I will try as many as I have to until I find something that works."

• Autumn
• Taken for 1 to 2 years
• April 5, 2019

Trintellix (vortioxetine) "I’ve read many of these posts. I too had nausea (would throw up within 15 minutes of taking Trintellix pill, every single day). My doctor told me to take an anti-nausea med like Zofran (or generic) 30 minutes before I take this pill. It worked. No nausea at all if you follow that rule. Please try that if that’s your only hold up. I’ve been on it about 2 years. I STILL have to take a Zofran 30 minutes before Trintellix or I will puke. Also, take it around bedtime."

• hbea
• Taken for 1 to 6 months
• May 14, 2015

Trintellix (vortioxetine) "I only stopped taking this medication because I switched insurances and the new company will not cover it at all! Being off of it, I realize what a huge difference this medication made. I took Brintellix for 4 months. I had some difficulty the first couple weeks, to be honest, with sleep. Taking the medication in the evening made sense for me, I slept better vs. taking it in the day time, I slept worse. I ended up not needing to take any of my anti-anxiety pills after a month! My arousal was not hindered at all. Brilliant medication, thank you to whoever discovered this one."

• Doing...
• Taken for 1 to 6 months
• December 22, 2017

Trintellix (vortioxetine) "After having been on sertraline for years for MDD at increasingly higher doses and hence pesky side effects I'd had enough, felt like I was crawling out of my skin with anxiety, which it was supposed to treat. Plus I weighed more than I wanted to in spite of exercise and diet. Doc prescribed Trintellix and holy cow, I will never take sertraline again. I have had no side effects, well, dry skin, but that I can manage. No brainy-type side effects, I don't feel sedated at all, but I do feel calm and no depression. No longer craving carbs. I only wish I'd known about this medicine sooner. I feel like myself! The pharmaceutical company has a "loyalty program" for helping with the cost, do check it out."

• Female
• Taken for 6 months to 1 year
• March 26, 2017

Trintellix (vortioxetine) "I took all sorts of meds to test with most horrible side effects. Finally one day my doc had me try Trin 20 mg and my life changed. I read negative reviews and was scared but I have had no side effects except for some weight gain. I had a family member that got severely sick and I was by their bedside for 3 months though I would get depressed I never had a dark dip (you know what I'm talking about) I bounced back quickly. I recommend trying this. Just try and in a week u will know. Drug is super expensive. Use coupon. Call the Pharma company. see what happens... it may just change ur life. Oh... forgot to mention that I just started my own business after years of working for idiots getting fired. I doubt I could do this without this med."

• Paula
• Taken for less than 1 month
• February 9, 2020

Trintellix (vortioxetine) "I would give Trintellix a -100 if I could. My psychiatrist was telling me how great this drug was for all his other patients but this was the worst drug I've ever taken. I would never recommend this as I became severely depressed with daily thoughts of hurting myself and thoughts of suicide. I was literally crying every day until I was able to get off of this."

• Cleob...
• Taken for less than 1 month
• September 14, 2018

Trintellix (vortioxetine) "I had been on Lexapro for MDD but I had gained weight and gotten to the point where I barely wanted to leave my house. I’m now on Trintellix and I have a brighter mood and am more energetic and interested in life. I would recommend this drug. I haven’t had any of the gastrointestinal symptoms."

• Saved...
• January 7, 2017

Trintellix (vortioxetine) "My husband had been on every drug and drug combo available- nothing worked for his anger, depression and crippling anxiety. This has been a GOD-SEND! After 24 years of marriage, I finally feel like I found the loving, kind man I fell in love with. No side effects at all, much more stable moods, and soundly sleeping at night. He also takes Seroquel at bedtime."

• Bipol...
• March 18, 2016

Trintellix (vortioxetine) "I noticed a great improvement in my depression soon after introducing Brintellix to my other meds (latuda, Lamictal, xanax, doxepin, adderall) I also noticed it causes me nausea and vomiting! But I really like this one...hate that it makes me sick! Someone recommended putting it in peanut butter and I think I'll try that because it works really well for me! I've taken my son out like everyday, I couldn't be a "good" mom before brintellix! Like seriously have never felt better! Vomiting sucks tho, I hate it... really hope peanut butter trick works!"

• V77xx
• Taken for less than 1 month
• March 27, 2024

"I took it only for 12 days at 5mg. I was hoping, after trying many types of antidepressants during the last 15 years, that this one would have helped. It took away the brain fog. It activated me and I had more motivation and focus during the day, but gave me horrible insomnia which affected my wellbeing during the day. This is not good because I was able to sleep before this medication. After struggling with insomnia for 2 years, I was again able to sleep but this medication brought me back to square one. So I was told it is better to discontinue it and try a new one. I am now tapering it off."

• Jade
• November 1, 2019

Trintellix (vortioxetine) "After being on a variety of antidepressants for over 20 years this is the best that I have taken. I feel so much better. I have had migraines and I don’t get headaches anymore. The only drawback is I’m hungry all of the time so I’m going to have to watch what I eat. If you’ve been on other meds and they have run their course I hope that you try this when it works for you as well that is working for me. Currently on 10 mg a day."

• bnicole
• Taken for 1 to 2 years
• July 27, 2022

Trintellix (vortioxetine) "Trintellix is easily the best experience I’ve had with an antidepressant (and I’ve tried several). Major depressive disorder for over 10 years and this med has truly changed my life. The only negative side effect I’ve experienced is some nausea occasionally for about 10-30 min after taking but anyone with depression knows that is nothing compared to regular symptoms. I will say that I found this med took a lot longer to work than others in the past (a full 6-7 weeks) but it is so worth it once it does! Would highly recommend to anyone on the fence. Don’t pay attention to the negative reviews, try it for yourself because these meds really do affect every person so differently!"

• Sailo...
• Taken for 2 to 5 years
• June 12, 2017

Trintellix (vortioxetine) "30 years of battling depression - many medications over those years with either undersirable side effects (weight gain, 'flat-lining', anxiety provoking), or meds that worked well only to lose efficacy over time. Trintellix is a blessing - I have used it since the 1st month it became available - highly compatible and effective, no side effects, and if anything my mind seems a bit sharper. Only drawback - my private insurance treats it as a category lll, so it is very very expensive - even with the coupons I still pay $258/month - but I won't go back to anything else."

• Anony...
• Taken for 1 to 2 years
• October 4, 2018

Trintellix (vortioxetine) "I have severe MDD and PTSD. When I started trintellix over a year ago, it was very helpful. However, the effects seem to have worn off a bit. That said, I haven’t noticed any negative side effects whatsoever and actually lost weight while on it, and it DID work in the beginning. So I would recommend this drug, especially since it worked for me more than any other antidepressant and hasn’t come with any of the negative side effects. "

• Nadethi
• Taken for less than 1 month
• November 2, 2019

Trintellix (vortioxetine) "I suffer from both depression and anxiety. I have been through hell the past 7 + months since paroxetine stopped working after many years of it being completely effective for me (as in took away all anxiety, obsessive thoughts, and depression). Since then I have tried Lexapro, Prozac, and now Trintellix. I even took a GeneSight test that said Prozac and Trintellix will be metabolized normally for me. Well, 5 weeks on Prozac I was severely depressed and having suicidal thoughts, so I stopped taking it. Now 3 weeks in on Trintellix just 5 mg (I took my first 10mg dose yesterday)and it's even worse. I am very agitated, can't eat anything- trying to eat makes me nauseous even though I'm hungry, can't sleep. I have more energy, but I'm also obsessing about whether my life is worth this. I can't relax, which I was at least able to do in the evenings when I wasn't taking any antidepressant. This is pretty bad, so I'm going to stop taking it. Discouraged again."

• today...
• May 4, 2017

Trintellix (vortioxetine) "This medication was a life changer for me. After struggling with debilitating depression and anxiety and trying several SSRIs my pdoc did a gene test which uncovered that my body doesn't tolerate SSRIs, So he put me on trintellix which is an atypical antidepressant. I finally started feeling the light at the end of the tunnel. I started with 10 mg upped to 20mg . I am so grateful for my doctor for thinking outside the box and get me on the road to recovery. The first few weeks I did experience severe GERD and even took a PPI for it. But after a few weeks it thankfully subsided. I started to see improvement after 8 weeks."

• AMYZING
• Taken for 1 to 6 months
• April 7, 2019

Trintellix (vortioxetine) "I been on lexapro for 20 years then that stopped working, than tried many other for my panic disorder, also took and Genesite test. It showed trintellix would be a good match and on it 6 weeks, so far so good, I had been having panic and depression, and depersonalization which extremely hard ,but lets hope it gets better and better."

• capta...
• Taken for 1 to 2 years
• May 14, 2016

Trintellix (vortioxetine) "I have been on Brintellix for a year now and this drug has definitely had a positive impact on my quality of life. The profound sadness that was my unwelcome partner for many years has for the most part dissipated. On most days, my mood is good, but the strange thing is that even though my mood is not depressed, I have little motivation to do activities that would bring me pleasure. I very rarely engage in hobbies, watch TV, read books, listen to audio books, or exercise, so I have a lot of free time in which I do nothing. Amazingly, my mood still remains relatively stable. But it is a frustrating mindset and so I'm going to ask my psychiatrist to lower the Brintellix or adjust one of my four other psychotropic meds I also take daily."

• Noah...
• August 5, 2019

Trintellix (vortioxetine) "I’ve been using Trintellix for almost three months. I started 10mg for like 10 days then increased to 20mg, I’d like to share my experience with you guys. During those 3 months I had these side affects : 1. Nausea : at the beginning For 12 days then it’s gone. 2. insomnia : at the beginning and continue for Two weeks then it’s gone. 3. Itching: started in the second month of using but it last only for one week and it’s gone. I don’t experience any changes in my weight. Right now I’ve completed 3 months of using and I don’t have any side affects. My problem is that I don’t feel any improvement in my Major Depression "

• Kkano
• Taken for less than 1 month
• December 25, 2019

Trintellix (vortioxetine) "My doctor did a swab test on me to find the medication with the best reaction to my dna and Trintellix was on that list. I took 5 mg pills for a week and then had to go onto 10mg after that. As soon as I started I noticed really awful nausea I’d get after taking the pill and it would last all day. Once I started taking 10mg not only did the nausea get worse but I started vomiting everything I put in my stomach. It got so bad I ended up going to the ER to get fluids in me. I have heard good things about Trintellix but wow it really has not been good for me"

• prox
• Taken for 1 to 6 months
• November 18, 2014

Trintellix (vortioxetine) "I've been on Brintellix for just over 2 months and it's helped my depression tremendously. I've been on several SSRIs and this is far and away the best one I've tried. It kicked in a little faster and the lack of side effects is remarkable. (I was irritable when I increased my dose from 5mg to 10mg, but it subsided after a month and I took Klonopin as needed to help. I also noticed some mild scalp tingling which another person mentioned.) No sexual side effects, no weight gain, no TMJ, no night sweats! I'd recommended titrating up SLOWLY if you have anxiety/irritability (cut those annoying egg-shaped pills in half) and taking it with a meal to prevent nausea."