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Quetiapine for Obsessive Compulsive Disorder User Reviews

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 8.6 out of 10 from a total of 46 reviews for the off-label treatment of Obsessive Compulsive Disorder. 76% of reviewers reported a positive experience, while 4% reported a negative experience.

Quetiapine rating summary

8.6/10 average rating

46 ratings from 50 user reviews.

Compare all 36 medications used in the treatment of Obsessive Compulsive Disorder.

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Reviews for Quetiapine

  • lorie
  • Taken for 1 to 2 years
  • December 11, 2019

"I started taking Seroquel about a year ago to help with insomnia caused by OCD and anxiety. It helped me incredibly. I took either 25 mg or 50 mg each night to help me sleep. It has helped so much with my OCD and taken the edge away from my anxiety. I used to get very fixated on intrusive thoughts to the point where I couldn't sleep, but with this medication, I can actually slow my thinking down, rationalize, and calm down. I just want to say, if you’re struggling with OCD and anxiety and cannot sleep, please reach out for help. Sleep deprivation can worsen your symptoms and thinking! Please reach out for help if you are struggling with any kind of mental health issue."

10 / 10
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146 Report
  • Jjano
  • Taken for 5 to 10 years
  • September 14, 2020

"I suffered from severe OCD for 30 years. After trying everything my doctor put me on a combination of quetiapine 100mg a day and prozac 40mg a day. It has given me my life back. The OCD still lurks in the background but now I can make plans, I sleep well and I can have fun. My only regret is the waste of so many years of my life when there is a drug combo that works. Im in the uk so fortunately our meds are free"

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96 Report
  • ADee
  • Taken for 5 to 10 years
  • March 20, 2019

"I started on Seroquel in January 2013 after a hospitalization. My treating psychiatrist prescribed it after I discussed my challenges with ruminating thoughts, going back to my early youth. What a godsend this medication has been for me. No more thinking about the same thing, over and over and over again. Even though Seroquel is used off-label for rumination, it really has improved the overall quality of my life. So for those that suffer with ruminating thoughts, please know there is hope!"

10 / 10
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120 Report

Frequently asked questions

  • hburn
  • Taken for 1 to 6 months
  • May 23, 2018

"I take Seroquel for anxiety/OCD, which is rather severe, and I never thought I could feel as good as I do now. I was always scared of Seroquel because of the potential weight gain, but I find my appetite is actually less now! My head is clear, my thoughts make sense, I literally cannot ruminate no matter how hard I try. It's very bizarre but it's incredible. I feel like I have a life now. The only reason I didn't rate it a 10 is because it gave me headaches/muscle tension in the beginning, but that's slowly fading which is great. Don't be scared of Seroquel, it might save your life."

9 / 10
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123 Report
  • Sharm
  • Taken for less than 1 month
  • March 30, 2018

"The quetiapine completely took away my intrusive thoughts, I couldn't talk to people as the intrusive thoughts was always there. I couldn't listen to music because the intrusive thoughts would come, couldn't go out with friends. Now this medication has changed all that I was battling this for years, and they finally put me on the right medication "

10 / 10
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101 Report

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  • luzma...
  • Taken for less than 1 month
  • March 15, 2021

"This drug is the only drug I have ever taken that helps my massive anxiety and suicidal depression. I believe I am a high functioning borderline, and I was spinning out of control after a traumatic breakup with my partner. This drug saved my life! It worked immediately, the first night I took it. It took away all my suicidal thoughts that were completely overwhelming me — likely saving me from a stay at a psychiatric hospital. It has also helped eradicate obsessive thoughts about my ex partner and compulsion to contact my partner. I feel calm and relatively reasonable. I’m an attorney, and I can now focus on work so much better! Before, I was simply overwhelmed and could not focus enough to comprehend documents and client comments/emails. I don’t know how this drug works, but what a godsend! I’m on 50mg nightly. I am so grateful!"

10 / 10
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53 Report
  • CRB
  • Taken for 5 to 10 years
  • April 27, 2024

"Omg!! I wish I had this growing up! OCD thoughts where you can’t stop thinking of one thing or everything from the day. This works! My brain finally turns off at night and it’s a game changer. I thought I had insomnia. Nope, I had OCD thoughts of specific things that just randomly happen in life. And you can’t stop thinking and fall asleep. I love you Seroquel."

10 / 10
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3 Report
  • Sandie...
  • October 19, 2008

Seroquel (quetiapine) "I suffer from extreme anxiety and obsessive-compulsive disorder. I was prescribed Seroquel 25 mg (one in the morning and two at bedtime). This medication has done wonders for me in a very short period of time (one week). In low doses, Seroquel is effectively taking the edge off life, and I'm a much happier person. It's like a miracle drug for me, and I can't imagine going back to life without it."

10 / 10
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130 Report
  • Raman...
  • Taken for 1 to 6 months
  • June 20, 2021

"In 2015 I was on Lithium 900mg and Qutipin 600mg. I had these strange superstitions along with these vicious and intimidating thoughts. When I told my psychiatrist about this the first thing he did was to stop Qutipin. Then he introduced Olanzapine which I found very helpful in the beginning when it was on low dose. But when the dose increased Olanzapine could do very little to stop my OCD. I became dumb and dormant. I quit football. For the next 5 years I was on high dose of Olanzapine, sometimes more than 15mg. I could do nothing about my future. I had no goals. All I was doing was eat fast food. But in April 2021 I decided to quit Olanzapine and start Qutipin after consulting my doctor. I started decreasing Olanzapine by 2.5mg and increasing Qutipin by 50mg. On decreasing Olanzapine to 2.5mg and increasing Qutipin to 350mg I got great satisfaction. My will/drive was increased, OCD symptoms were completely gone, I also started playing tennis and my short term memory got improved."

10 / 10
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30 Report
  • Miss...
  • Taken for 1 to 6 months
  • February 1, 2018

"I have been quetiapine for just over a month. It was prescribed for me by a psychiatrist as I have OCD. The outcome has been amazing, I cannot believe that it seems to have taken 'the edge off' the severe anxiety I had as a result of my OCD. I don't feel spaced out but there is a feeling of 'numbness' I guess is the only way that I could describe it in my head. My psychiatrist has increased the dosage from 75mg to 100mg but I think I may just stay at 75mg as I don't want to feel 'out of it'. I would recommend it to anyone who has severe OCD. Prior to taking this medication I was at rock bottom unable to get dressed and had no appetite. I feel as though I have got my life back. I would prefer not to be on medication but it is the best option as the alternative is feeling so low and depressed as a result of the anxiety caused from my OCD ."

10 / 10
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52 Report
  • Johnny
  • April 27, 2016

"This is hands down the best drug I have taken for my OCD. The first dose had a dramatic impact on me. I take 50mgs one hour before bed and I sleep a solid 9 to 10 hours eveynight. Got up the next and had so much energy that I was looking for something to do while on vacation. This drug is awesome!!!"

10 / 10
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58 Report
  • Delus...
  • January 24, 2009

Seroquel (quetiapine) "I was diagnosed with OCD and doctor put me on Zoloft and for some time I was okay then started getting side effects. I went back to doctor and he gave me Seroquel and instantly after taking first dose of 25mg I started to feel a lot better, like a new man. It really helped me sleep well without fear in my thoughts, so I really gave BIG 10 for this drug for helping me live normal life ."

10 / 10
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93 Report
  • uuerh
  • Taken for 1 to 2 years
  • May 18, 2024

"I've been using Quetiapine for my OCD symptoms for the past 1 year, and the results have been quite positive. Initially, I was skeptical about its effectiveness, but I've noticed a significant reduction in my obsessive thoughts and compulsive behaviors since starting the medication. Quetiapine has helped me better manage my anxiety levels, allowing me to engage more effectively in therapy and daily activities. Overall, it has been a valuable addition to my treatment regimen for OCD."

10 / 10
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1 Report
  • anxie...
  • June 20, 2015

"I was on Seroquel for a long time and then I overdosed on it and was taken off. For the next 2 years I suffered from horrible anxiety, paranoia, ocd, panic etc. and ended up in the hospital twice for very long stays (2 months). I had ECT and nothing seemed to help. Finally my therapist suggested to the psychiatrist that he put me on Seroquel. It is like a miracle drug! I no longer have anxiety and OCD"

10 / 10
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56 Report
  • Tif
  • Taken for 2 to 5 years
  • December 5, 2023

"So, I take Seroquel off label for MDD and insomnia (not approved for insomnia anymore, but it still helps me). My psychiatrist and I, this year, decided to increase my dose to 100mg at night. It took about 1 week for the effects to take place, but after that week, my mind was at ease in a way I had not known was possible. I had been using therapeutic techniques to handle my OCD symptoms. When I realized I was feeling such immense relief from my intrusive thoughts, I did some research and found this page. I had grown so accustomed to living with my OCD and the intrusive thoughts; I didn't realize how much it had been impacting me until I felt relief. One of the biggest issues I had with OCD was relationships. My relationship OCD is gone. I occasionally have symptoms relapse when I'm stressed, but it's nothing like it used to be."

10 / 10
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6 Report
  • jonny...
  • August 31, 2016

"Excellent even at 12.5 dose,--need to split a 25mg tab in half, which is nearly impossible with some generics. I wish they'd make a lower dose. Have never taken a stronger dose for fear of over-sedation, though I get accustomed to the low dose quickly. A godsend. I highly recommend it."

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46 Report
  • Ioanna
  • October 8, 2019

"I suffer from OCD. I am on 60 mg paroxetine and 100mg quetiapine. I hate the fact that I have to take an antipsychotic ☹️☹️. I would love to go off it since my main fear is that I am crazy. It has helped me though, I think."

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31 Report
  • Poppy
  • Taken for 1 to 6 months
  • April 28, 2021

"This medication has saved my life. I was suffering from OCD and depression, it was a terrifying combination as I couldn't stop thinking about how terribly depressed I was. I take 150mg at night and my symptoms are pretty well managed. I also take venlafaxine 300mg alongside."

10 / 10
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22 Report
  • vstud
  • Taken for 2 to 5 years
  • April 3, 2021

"This is the only thing that are able to keep my thoughts under control. I don’t believe that OCD will be under control with this medicine only because in many cases these condition are followed with depression and anxiety. I also take Fluoxetine and Pregabalin. I feel a huge relief that allows me to function and learn what my therapist says. True life saver combo."

10 / 10
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22 Report
  • Mac-l...
  • April 23, 2013

"I suffer from O.C.D and Obsesive Compulsive personality disorder. I have had it since aged 12. I'm now in my 40's. For the last three years I've been on a high dose of quetiapine 600 mg nightly, I also take Lustral during day.. They have helped me so much, it's first time in years I've felt more 'normal'. Before I was very manic, etc., this has calmed me down a great deal. BUT, I'm always tired, not much energy, my weight has gone up, I used to exercise before but struggle now, BUT I'd rather be like this than manic, panicking, and a nightmare to live with!! I'm married with 4 children, it's a shame they have seen me at my worst many a time, which I feel terrible about. But now I'm on this medicines I'm a different person."

10 / 10
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55 Report
  • Viktor...
  • December 4, 2008

Seroquel (quetiapine) "Seroquel has made a day and night difference in my life. I have huge anxiety issues and OCD. I've been taking 200mg/night for a few years now. It's not for everybody with OCD, but it has been a life saver for me."

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63 Report
  • Idk
  • Taken for 6 months to 1 year
  • August 31, 2019

"Struggle with a lot of insomnia due to OCD and anxiety, I often times have trouble falling asleep. But this medication lets me get 8 hours of sleep every night which allows me to cope with the anxiety and OCD. It really helps with unwanted OCD thoughts, lets thoughts come and go better. It doesn’t completely get rid of my very general daily anxiety but it helps me sleep which is very important to me!! Also I’ve experienced no weight gain, only side effect would be if I take it late 12 am -1 am and night and have to get up early the next day I do feel a little drowsy for a bit."

10 / 10
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26 Report
  • Pound...
  • July 21, 2018

"I was surprised that other people say how this puts them to sleep as it did the exact opposite to me. When I first took it I started feeling very disorientated & anxious, and after barely falling asleep I soon woke up with a panic attack. I continued taking it cuz the doctors pressured me but the more I took it the harder it was for me to fall asleep & I started having very painful heart palpitations 1 hour after I took the quetiapine. I noticed that it has a mood-stabilizing effect and also suppresses OCD. After a few days all my obsessions and intrusive thoughts greatly decreased. After a few months of taking I even started taking some other pills for sleep cuz Quetiapine ruined my sleep but it did make me more stable during the day. The side effects I had are: insomnia, feeling tired in morning, heart palpitations (which greatly decreased the longer I took it), and hunger for carbs. As a sleep-aid I give it a 1/10 - its awful and even ruins my sleep, as a mood-stabilizer 7/10, and as an anti-OCD 8/10."

6 / 10
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30 Report
  • Accur...
  • Taken for less than 1 month
  • February 27, 2019

"I have taken 100mg seroquel for depression before (a few years back) and now I take 25mg quetiapine (generic) along with escitalopram 20mg for depression and intrusive thoughts. It helped with my intrusive thoughts, I didn't have to do my mental compulsions as much and reduced my feelings of guilt. Does make me wake up later than usual and also shakiness after taking it at night. I didn't gain weight on the medication, however I do keep up with exercise as usual."

8 / 10
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25 Report
  • Alma
  • March 22, 2022

"I have been taking quetiapine for a year. The psychiatrist gave me quetiapine to lower my anxiety and OCD. I had horrible images in my head, I could not sleep. Quetiapine helps me a lot to cope with anxiety and OCD, significantly improve my sleep, mood, everything. I was bad, I was devastated, then I asked for help and this has helped me, I am another person, I found myself! I never thought I would say this but quetiapine saved my life. Do not hesitate, ask for help, I believe in myself that you will succeed! A 10 for quetiapine!"

10 / 10
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12 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.